PROPPI

Pantoprazole is a selective "proton pump inhibitor", a medicine which reduces the amount of acid produced in stomach. It is used for treating acid-related diseases of the stomach and intestine.

Pantoprazole Injection is indicated for the treatment of gastric ulcer, duodenal ulcer & gastroesophageal reflux disease (GERD).
Pantoprazole is used for treating:
Adults and adolescents 12 years of age and above:
♦ Reflux oesophagitis. An inflammation of your oesophagus (the tube which connects your throat to your stomach) accompanied by the regurgitation of stomach acid.

Adults:
♦ Stomach and duodenal ulcers.
♦ Zollinger-Ellison-Syndrome and other conditions producing too much acid in the stomach.

Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Absorption: Well absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: 99%.
Excretion: Urine (as hydroxymetabolites); 4 hr (elimination half-life).

May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.

♦ Patients sensitive to aceclofenac, paracetamol & serratiopeptidase.
♦ Contraindicated in patients with severe ulcer gastrointestinal bleeding and hypersensitivity.
♦ Aceclofenac and Serratiopeptidase is contraindicated in patients with asthma, renal or hepatic disorders, hypertension and porphyria.

Diarrhea, nausea, headache, indigestion, heartburn, abdominal pain, flatulence, feeling sick, dizziness and rash.

Caution should be exercised in patients with history of Crohn's disease, bruising, heart, liver, or kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, elderly, during pregnancy, alcohol-dependent patients, and breastfeeding.
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

Store it in an airtight container in a cool dry place. Protect from light.